Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder
نویسندگان
چکیده
منابع مشابه
Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression.
OBJECTIVE The authors tested the hypothesis that concentrations of the pain-transmitting neuropeptide substance P are elevated in the CSF of patients with major depression or posttraumatic stress disorder (PTSD), which have overlapping symptoms. The authors also sought to determine if CNS substance P concentrations change on provocation of symptoms in PTSD patients. METHOD The authors measure...
متن کاملIncreased neuropeptide Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.
We investigated the possible relation between neuropeptides and cerebral vasoconstriction in samples of ventricular or cisternal cerebrospinal fluid from 14 patients with subarachnoid hemorrhage. Neuropeptide Y, calcitonin gene-related peptide, atrial natriuretic peptide, and pituitary polypeptide 7B2 were present in the cerebrospinal fluid of these patients. Concentrations of calcitonin gene-r...
متن کاملA Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder
Background Anxiety and trauma-related disorders are among the most prevalent and disabling medical conditions in the United States, and posttraumatic stress disorder in particular exacts a tremendous public health toll. We examined the tolerability and anxiolytic efficacy of neuropeptide Y administered via an intranasal route in patients with posttraumatic stress disorder. Methods Twenty-six ...
متن کاملTrauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels.
BACKGROUND Exposure to uncontrollable stress reduces baseline plasma neuropeptide-Y levels in animals. We previously reported that baseline plasma neuropeptide-Y levels, as well as neuropeptide-Y responses to yohimbine, were lower in combat veterans with posttraumatic stress disorder, but we were unable to determine whether this was attributable to posttraumatic stress disorder or trauma exposu...
متن کاملBlood pressure and cerebrospinal fluid norepinephrine in combat-related posttraumatic stress disorder.
OBJECTIVE Central nervous system norepinephrine (NE) is normally involved in blood pressure regulation, but it is pathophysiologically elevated in posttraumatic stress disorder (PTSD). METHODS We monitored blood pressure while performing serial cerebrospinal fluid (CSF) sampling for 6 hours to determine CSF NE concentrations in men with combat-related PTSD (n = 11) and in healthy men (n = 8)....
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2009
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2009.04.037